Clinical characteristics of primary hyperparathyroidism

Abstract：Objective To analyze the characteristics of PHPT patients of our hospital. Methods Retrospective analyze 82 PHPT patients who hospitalized in our hospital from 1974 to 2006,male 41,female 41 ,age 16～83 years,course 1 month ～40 years. All of the final diagnosis was PHPT clinically .while 67 were confirmed by pathology. Results (1)The number of diagnosed PHPT patients was increasing year by year, the cases diagnosed in 2002-2006 were more than the sum of past years. (2) The first visit department was widespread for PHPT patients, up to 47.6% went to urology depart-ment firstly,while only 24% went to endocrinology department. (3)Clinical presentation;42.7% patients presented simple urinary system calculus, 15.9% ostalgia with urinary system calculus, 17.1% simple ostalgia, while 20.7% with pathologic fracture,and 7.3% chronic renal failure,3.6% peptic ulcer,2.4% chronic pancreatitis. 69.5% occurred typical hypercalcinemia and hypophosphatemia,30. 5% revealed hypophosphatemia chiefly. (4)The coincidence rate between the examinations preoperation and pathology :B type ultrasound 64. 5% ,CT scan 37.3% .~(99m)Tc-MIBI scan 90%. (5)Pathology presentation; 73% single adenoma, 17.9% hyperplasia,2.9% adenoma with hyperplasia, 1.5% carcinoma,other 4. 5% only seen some parathyroid tissue. Conclusion PHPT patients have various clinical presentation, so there are gen-erally missed diagnosis and misdiagnosis. we should investigate serum calcium, phosphate and PTH level to exclude PHPT.