Detection of hepatitis B virus pre-C region mutation in cases of chronic hepatitis B and its relationship with IFN treatment
SUN Guo-jun
CUI Wei
LI Zhi-wei
Abstract：Ohjective To investigate the relationship between hepatitis B virus pre-core region 1896 site mutation in cases of chronic hepatitis B and IFN-alpha treatment. Methods 200 patients with chronic hepatitis B were randomly divided into experimental group(n=100) and control group(n=100). The patients in experimental group were treated with regular liver-protective drugs and IFN-alpha, while Control group patients received only regular liver-protective drugs for 6 months. PCR-RFLP were used to detect hepatitis B virus(HBV) DNA with pre-C region 1896 site mutation in two grops pre and post treatment. Results The mutation rates before interferon treatment were 20% (20/100) and 18% (18/100) in experimental group and control group, respectly. After treatment, the effective rates in experimental group were 60% (12/20) and 50% (40/80) in Patients with Chronic Hepatitis B variant and wild strain virus Infection,respectly. The ef-
fective rate in experimental group was significantly higher than that in control group. Conclusion IFN-alpha therapy was not correlated with genomic variability of the core region.
Keywords：HBV DNAmutationIFN-alpha
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1030-1032 )