The clinical value of measurements of serum SA, EMA and GPDA in the diagnosis of gastric cancer

XIANG Wen-kun; XIONG Feng-bao; YANG Tie-yi; FU Suo-lin

Abstract：Objective To study the clinical value of serum SA, EMA and GPDA in the diagnosis of gastric cancer. Methods To detect serum SA,EMA and GPDA in 30 patients with gastric cancer patients,25 patients with gastric precancerous lesions and 35 patients with non-atrophic gastritis with electronic gastroscope and pathological examination confirmed, compared the differences betwwen the groups, and analyze the relationship between the expressions of them and clinical biology of gastric carcinoma. Results The serum concentrations of SA and GPDA in gastric carcinoma are remarkably higher than those in non-atrophic gastritis and gastric precancerous lesions (P < 0.05). Serum EMA is not a valuable marker in the diagnostic of gastric cancer(P >0.05). The concentrations of GPDA in non-atrophic gastritis group are agerelated(P<0.05) and the concentrations of SA in the invasion stage is obviously higher than the localized stage(P< 0.05),There are no obvious correlations between the levels of the other groups with the clinical biology behavior of gastric carcinoma (P>0.05). Conclusion It has an important reference value for the diagnosis of gastric cancer to detect serum SA and GPDA. SA and GPDA together can improve the accuracy of the diagnosis of gastric cancer. EMA serum possibly has no diagnostic value for gastric cancer. The expressions of SA, GPDA in serum are related to the biology behaviors of gastric carcinoma, and the concentrations of SA, GPDA in serum is helpful in judging metastasis and recrudescence, and monitoring prognosis.