The incidence and risk factors of chemotherapy-induced liver disease of the patients with acute non-lymphocytic leukemia
YUE Lan-zhu
FU Rong
RUAN Er-bao
OU Wen
HANG Yong
WANG Guo-jin
WANG Xiao-ming
HU Hong
SONG Jia
GUAN Jing
WU Yu-hong
WANG Hua-quan
XING Li-min
LI Li-juan
WANG Jun
SHAO Zong-hong
Abstract：Objective To investigate the incidence and risk factors of chemotherapy-induced liver disease of AML patients. Methods Liver disease was classified into three grades as mild,moderate and severe according to the criteria established on European Drug Conference in 1990. Seventy cases of AML patients were studied who received treatment in the hematological department of General Hospital of Tianjin Medical University from 1997 to 2006. Statistics methods such as Chi-square test and Logistic Regression were used to investigate the correlation between the incidence and the risk factors of liver disease. Results The incidence of liver disease of seventy AML patients was 65.7%, including 38.6% mild,17.1% moderate and 10.0% severe liver disease. Single factor analysis showed that infection,blood transfusion, synchronous use of penicillin,cephalosporins,aminoglycosides, azoles could increase the incidence of liver disease (P<0.05); Liver disease was more common in the treatment of inducing remission and the regimen of ATRA(P <0.05); Glutathione was a protecting factor(P < 0.05). The incidence of liver disease was not significantly correlated with age, gender, types of leukemia, or the regimens(P > 0.05). Multivariate factor analysis showed that infection and synchronous use of cephalosporins were independent risk factors of liver disease(P<0.05). Conclusion The risk factors of chemotherapy-induced liver disease include infection, synchronous use of cephalosporins, treatment of inducing remission, and regimen of ATRA. Prophylactic use of glutathione could decrease the incidence of liver disease.
Keywords：liver diseasechemotherapy-inducedleukemiaacutenon-lymphocytic
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1009-1011 )