Relationships between the TIMP-1,TIMP-2 and the level of HA,PCⅢ,CⅣ and LN in the serum of patients with HBV infected
ZHU Chuan-long
NIE Qing-he
GAO Ren-tao
LI Yi
ZHAO Zong-hao
Abstract：Objective To explore the relationships and significance among the tissue inhibitor of metalloproteinases-1 (TIMP-1), tissue inhibitor of metalloproteinases-2 (TIMP-2), hyaluronia acid(HA), procollagen type Ⅲ (PC Ⅲ) , procollagen type Ⅳ (CⅣ) and laminin(LN) in the serum of patients with HBV infected. Methods The serum TIMP-1 and TIMP-2 were detected with enzyme-linked immunosorbent assay(ELISA),the serum ALT levels were measured with totally automatic enzymatic method,and the other markers with RIA in 498 hepatitis patients as well as in 100 healthy controls. Results Serum levels of the markers were higher in the patients than those in the healthy controls,and had signifi-
cant difference(P < 0.05), except the PCⅢ, CⅣ, LN, ALT level of chronic HBV carrier and the CⅣ level of mild chronic hepatitis. Among the various types of patients with HBV infected,only the serum TIMP-1 and TIMP-2 level constantly increased from acute hepatitis to liver cirrhosis, and difference was found between chronic HBV carrier and acute epatitis (P < 0.05). There were positive correlations between serum TIMP-1/TIMP-2 and HA, PCⅢ, CⅣ, LN, ALT(P<0.05). Conclusion These markers may reflect the state of liver fibrosis in different liver diseases,and the serum TIMP-1/TIMP2 may be more reliable for diagnosis of liver fibrosis.
Keywords：TIMP-1TIMP-2hyalurunia acidprocollagen type Ⅲproeollagen type Ⅳlamininliver fibrosis
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1006-1008 )