The effect of diabetes on creatine kinase activity in streptozotocin- diabetic rats
Zhao Xin
Wang Hongfeng
Huang Guiyu
Maryam Bassirat
Robert D Helme
Abstract：Objective To study the influence of diabetes on the CK activity in different tissues of streptozotocin-induced diabetic rats. Methods Serum samples, heart and skeletal muscles, brain and bladder tissues were collected from both streptozocin-induced diabetic rats and control group. CK was measured by enzymatic method. Results The body weight, heart weight, and brain weight reduced significantly compared with control group( P ＜ 0.01), but bladder weight increased significantly( P ＜0.01). CK activity in serum and skeletal muscles in diabetic rats was significantly lower( P ＜0.01);CK activity in diabetic heart was lower( P ＜0.01),in brain it was lower too( P ＜0.05). An extremely higher CK activity in diabetic bladder was found( P ＜ 0.01). Conclusion Diabetes can result in a lower CK activity in serum,heart,brain,and skeletal muscles and may affect the energy metabolism in these tissues. A higher CK activity in diabetic bladder may reflect a functional compensatory mechanism.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 220-222 )