Effect of low tidal volume with positive end-expiratory pressure on oxygen metabolism in patients with acute lung injury
Abstract：Objective To explore the effect of low tidal volume with positive end-expiratory pressure (PEEP) on oxygen metabolism in 14 acute lung injury (ALI) patients.Methods 14 patients with ALI were optimally ventilated by Assist and Control(A/C),and PEEP was increased gradually for 30min,respectively.The concentration of FiO2 was kept constant.The parameters of oxygen metabolism were obtained by using Swan-Ganz catheter.Results At PEEP 1.47kPa,the maximal DO2 was obtained,the DO2 was decreased at PEEP 1.96kPa (P<0.05).MBP,PAP and CI were not significantly different from PEEP 0.49～1.47kPa(P<0.05).CI decreased at PEEP 1.96kPa(P<0.05).Cst was kept approximately(33.6±8.3)mL/cmH2O from PEEP 0.98 to 1.47kPa,but Cst was decreased at PEEP 1.96kPa(P<0.05).Conclusion The low tidal volume with a given PEEP can obtain constant Cst and reduce the effect on hemodynamics in patients with ALI,and obtain the maximal DO2.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 21-22 )