Clinical efficacy of concentrated growth factors-assisted guided bone regeneration in the treatment of vertical alveolar bone defects
YAN Zhi-qiang
LIU Ke
HUANG Yu-ying
Abstract：Objective To evaluate the clinical efficacy of concentrated growth factors(CGF)-assisted guided bone re-generation(GBR)in the treatment of vertical alveolar bone defects of single teeth.Methods Totally sixty patients with vertical alveolar bone defects of a single tooth treated at the Department of Stomatology,Beijing Yanqing District Hospi-tal from January 2023 to December 2024 were selected.Using a random number table method,patients were allocated in a 1∶1 ratio to a control group(n=30)and a CGF group(n=30).The control group received conventional GBR,while the CGF group received CGF-assisted GBR.Probing depth(PD)of the deepest site of vertical bone defect,bleeding index(BI),and alveolar bone defect height were compared between the two groups at baseline and 6 months postoperatively.Mastication limitation and swelling and pain degree at 12 h,24 h,48 h,72 h and 96 h,and the differences in adverse re-actions at 2 weeks and 6 months after operation were also compared.Results There were no statistically significant dif-ferences in baseline data(PD,BI and alveolar bone defect height)between the two groups(all P＞0.05).At 6 months postoperatively,PD and alveolar bone defect height in both groups were significantly reduced from baseline,with a more pronounced reduction in the CGF group(both P＜0.05).The CGF group exhibited significantly lower degree of mastica-tion limitation at 48 h and 72 h,degree swelling degree at 48 h,72 h and 96 h,and lower pain degree at 12 h and 24 h,as compared to the control group(all P＜0.05).No adverse reactions occurred in either group during the follow-up period.Conclusion CGF-assisted GBR is significantly superior to conventional GBR in the treatment of vertical alveolar bone defects.It not only effectively promotes bone regener-ation and improves clinical parameters such as PD and bone defect height,but also significantly reduces patients' postop-erative discomfort,thereby improving their postoperative quality of life.As a safe and effective biomaterial,CGF is wor-thy of promotion and application in the treatment of alveolar bone defects.
Keywords：alveolar bone lossconcentrated growth factorsguided bone regenerationperiodontal regeneration
Publication Date：2025-09-30
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：7( 564-569,577 )