Research progress on the role of forkhead box O1 in oral oxidative stress-related diseases
YE Yu-jia
TANG Jin-qiao
ZHAO Bin
MA Yan-ning
Abstract：Oxidative stress is an imbalance between the body's oxidative and antioxidant systems that initiates tissue damage by oxidizing lipids,proteins,and DNA,eventually leading to cell necrosis or apoptosis.Under the stimulation of various endogenous and exogenous factors,oxidative stress is triggered in the body and leads to related tissue damage,which promotes the occurrence and development of various oral diseases,such as periodontitis,apical periodontitis,peri-implantitis and oral cancer.Forkhead box O1(FoxO1),as a homeostasis regulator,can remove reactive oxygen species and regulate oxidative stress response.This paper takes the oxidative stress phenomenon of oral diseases as the entry point and reviews the research progress on the complex role of FoxO1 in regulating redox homeostasis in oral diseases,with the expectation of providing a theoretical basis for FoxO1 to be used as a new therapeutic target for oral diseases.
Keywords：forkhead box O1reactive oxygen speciesoxidative stressoral diseases
Publication Date：2025-07-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 472-480 )