Advances in research of the role of exosomes in regulating mandibular condyle growth and remodeling under stress stimulation
MIAO Ming-jun
ZHANG Jia-nan
LU Hai-ping
Abstract：Skeletal class Ⅱ malocclusion is a common orthodontic disease in clinical practice,often characterized by in-adequate mandibular development.Functional appliances are often used in clinical practice to guide the growth and re-modeling of the mandible during the peak period of growth and development of the patients.Its biological basis is that the condyle can undergo endochondral osteogenesis and is sensitive to changes in environmental stress stimulation.However,the specific mechanism by which environmental stress stimulation regulates condylar growth and remodeling is currently unclear.In recent years,researches have found that exosomes,as a paracrine intercellular communication substance,play an important role in intercellular communication and material exchange.This article will review the effects of exo-somes on condylar growth and remodeling,the effects of stress stimulation on exosomes,and the regulation of condylar growth and remodeling by stress stimulation through altering exosomes.
Keywords：exosomescondylemechanical stressgrowth and developmentbone remodeling
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 226-231 )