Research progress on the prevention and treatment of platelet-rich fibrin in medication-related osteonecrosis of the jaw
ZENG Ye-jian
WANG Jun
ZOU Hai-xiao
Abstract：Medication-related osteonecrosis of the jaw(MRONJ)is a severe complication that occurs in patients taking bisphosphonates and other related drugs,primarily manifested as jawbone necrosis.Currently,there is no widely accept-ed treatment for MRONJ,and the optimal approach remains controversial.Platelet-rich fibrin(PRF)is a second-genera-tion platelet concentrate that is easier to prepare compared to its first-generation counterpart,platelet-rich plasma(PRP).Additionally,PRF presents lower risks of immunogenicity and infection.However,the effectiveness of PRF as an adjunctive treatment for MRONJ in promoting healing and regeneration of soft and hard tissues is still not clear.This arti-cle aims to provide a comprehensive review of recent research progress on the application of PRF in MRONJ,hoping to explore its potential efficacy in both the prevention and treatment of MRONJ.
Keywords：medication-related osteonecrosis of the jawbisphosphonatesplatelet-rich fibrin
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 752-756 )