Research progress of modified titanium-based material in regulating macrophage phenotype and promoting immune osteogenesis
LIU Xiu-yu
LYU Hui-xin
ZHOU Yan-min
Abstract：Peri-implant tissue repair is an important factor that affects the success rate of the implant.At present,osteo-immunomodulation mediated by macrophages is one of the research hotspots of implantation,which focuses on promoting angiogenesis and accelerating bone remodeling.Implant surface treatment affects the polarization phenotype of macro-phages both adhering on the surface of the implant and in the peri-implant inflammatory microenvironment,thereby af-fecting early soft tissue healing and late osteogenesis after implant surgery.This article reviews the effects of different im-plant surface treatments on the polarization of macrophages and tissue repair mediated by them,aiming at finding the best opportunity and strategy for osteoimmunomodulation.
Keywords：osteoimmunomodulationmacrophageosseointegrationsurface modificationangiogenesis
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 742-747 )