Relationship between the prevalence of periodontitis and the level of choline metabolites in peripheral blood of patients with coronary atherosclerosis
WANG Yan
ZHOU Xin
HUANG Ling-yan
LI Bing
WU Juan
YANG Jie
LI Yi-min
XIE Wei-ge
XIE Si-jing
Abstract：Objective To study the correlation between the prevalence of periodontitis and choline metabolite levels in peripheral blood of patients with coronary atherosclerosis.Methods Totally 66 patients with coronary atherosclerosis diagnosed in Nanjing Chest Hospital from 2018 to 2020 were selected,and the patients were divided into the periodonti-tis group(45 patients)and the health group(21 patients)according to the oral examination results.The basic information of the two groups(age,body mass index,gender,smoking status,and peripheral blood glucose,low-density lipoprotein,high-density lipoprotein,triglyceride,and C-reactive protein levels)was compared.The level of peripheral blood choline metabolites[trimethylamine(TMA),tri-methylamine N-oxide(TMAO),betaine,choline,creati-nine,L-choline]was measured by liquid chromatogra-phy tandem mass spectrometry.The correlation between the prevalence of periodontitis and the levels of choline metabolites in patients with coronary atherosclerosis was studied via ordered regression analysis for the quartiles.Results The basic information showed no statistically significant differences between the two groups(P＞0.05).TMAO levels of peripheral blood in the periodontitis group[12.97(8.85,18.17)ng/mL]was higher than that in the health group[5.81(3.23,10.62)ng/mL],and the difference was statistically significant(Z=-3.297,P=0.001).Ordered regres-sion analysis showed that patients'periodontal condition was correlated with the peripheral blood TMAO levels(95％CI:-2.589--0.334,P=0.011).Conclusion Elevated peripheral blood TMAO level in patients with coronary atherosclero-sis combined with periodontitis suggests that periodontitis may promote the development of atherosclerosis by affecting the TMA metabolic pathway.
Keywords：trimethylamine N-oxideperiodontitiscoronary atherosclerosis
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 694-699 )