Research progress in the relationship between Ku and oral tumors
ZHANG Yun-jia
PAN Ya-ping
Abstract：Oral and maxillofacial region is one of the popular sites of the tumor, its incidence rate increases year by year and affects the quality of patient's life seriously. Previous studies have indicated that DNA damage is closely related to the occurrence and development of tumor. After DNA is damaged, body identifies the type of damage and initiates the repair mechanism to maintain body's normal state. Ku is one of the DNA repair protein, consisting of two subunits:Ku70 and Ku80, and plays a signifycant role in maintaining gene stability and integrity. In recent years, many studies have found that Ku in cancer tissues and adjacent tissues shows significant differences in expression. This paper reviews the expression of Ku in oral tumors, the related mechanisms, and its role in oral tumor progression prognosis of oral tumor.
Keywords：Kutumororal
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 308-311 )