Expression of miR-590 in the oral tissues of patients with oral lichen planus and oral squamous carcinoma
WU Yan
TIAN Hong-wei
DU Mei-yi
Abstract：Objective To investigate the expression of miR-590 in the tissues of patients with oral lichen planus and oral squamous carcinoma and study its role in the carcinogenesis of oral mucosal cells.Methods Twenty female and twelve male OLP patients (OLP group)and seventeen female and eleven male OSCC patients (OSCC group)were selected,who were pathologically diagnosed in Jinzhou Stomatological Hospital from March 2014 to December 2015.Twenty healthy matched volunteers served as control group.The expressions of miR-590 in oral tissues of the three groups were examined by realtime PCR.The difference among the three groups was statistically analyzed.Results The relative expressions of miR-590 were significantly higher in OLP (1.96 ± 0.52)and OSCC patients (2.75 ± 0.78)than those in the healthy controls (0.77 ± 0.34)(P ＜ 0.05).There were significant differences in the expression of miR-590 between the OLP group and OSCC group(P ＜ 0.05).Conclusion The expressions of miR-590 are higher in OLP and OSCC patients than those in normal controls;miR-590 may play a role in the carcinogenesis of oral mucosal cells.
Keywords：microRNAmiR-590oral lichen planusoral squamous carcinoma
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 48-51 )