Study on the condylar cartilage proliferation participated by DMP-1 in the process of mandibular functional protrusion
WANG Hao-ran
ZUO Yan-ping
YAN Bao-yong
MA Su-wei
LI Shuang
Abstract：Objective Objective To investigate the changes in the expression of DMP-1 in the condylar of a young rat during functional mandibular protrusion.This work also explores the function of DMP-1 in the cartilage proliferation,which provides experimental evidence for the clinical orthopedic treatment for bone type Ⅱ malocclusion.Methods Totally 70 healthy male Sprague-Dawleys (SD) rats at the age of 4 weeks were included in the study.The rats were divided randomly and equally into experimental group and control group.The mandibular protrusion bite plate appliances that were fitted to the animals in the experimental group were worn all day.No operation was performed in the control group.Five rats were executed in each group after 1,3,7,14,21,28 and 35d.Detect the expression and variation of DMP-1 by immunohistochemical method and cell image analysis system.Results On the 3rd day,the expression of DMP-1 in condylar cartilage was obviously enhanced in the experimental group.which reached to the highest level on the 14th day,IHS=85.67±4.51,which had significant difference (P ＜ 0.05) compared with control group,IHS=10.67± 1.53.Conclusion DMP-1 participates in condylar cartilage adaptive remodeling during the process of mandibular protrusion of rats,and promotes condylar cartilage proliferation and endochondral ossification.
Keywords：mandibular functional protrusioncondylar cartilagebone remodelingDMP-1
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 554-557 )