Comparison of diode laser and tacrolimus in the treatment of erosive-atrophic oral lichen planus
PENG Chuan-yang
JIANG Ai-jia
LI Yan-jie
ZHANG Ying
Abstract：Objective To evaluate the efficacy between low-level diode laser of 810 nm and topical tacrolimus in the treatment of erosive-atrophic oral lichen planus (OLP).Methods A total of 60 erosive-atrophic OLP patients were randomly divided into experimental and control groups,with 30 cases in each group.Experimental group received 810 nm diode laser as local irradiation therapy;the control group received drug treatmemt with tacrolimus gel (0.1％).Evaluations were performed once a month during treatment and at the 3rd month and the 6th month.Results Sign score,pain score,and lesion severity were reduced in both groups.No significant differences were found between the two groups.But in the follow-up period after treatment,the recurrence rate of the experimental group was significantly lower than the control group(P ＜ 0.05).Meanwhile,nine patients of the control group reported side effects after the first one week of drug application.No side effects were found in the experimental group.Conclusion Diode laser treatment is as effective as topical tacrolimus therapy without any adverse effects in the treatment of erosive-atrophic OLP.Diode laser therapy can reduce recurrence and its post efficacy is superior to tacrolimus.Diode laser therapy can be a promising alternative therapy in the treatment of erosive-atrophic OLP.
Keywords：diode laseroral lichen planuserosive-atrophictacrolimus
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 535-539 )