Research into the biological activity of vascular smooth muscle cells influenced by Porphyromonas gingivalis
WU Zhi-yao
ZHANG Ming-zhu
Abstract：Phenotypic alteration,proliferation,migration,calcification and other biological activity changes may occur in vascular smooth muscle cells,which have an important impact on the development of atherosclerosis (AS).Epidemiological surveys and experiments in vivo and in vitro have demonstrated that periodontitis is closely related to AS.Porphyromonas gingivalis (P·gingivalis) is recognized as one of the major pathogens of chronic periodontitis.The P ·gingivalis promotes atherosclerosis formation by way of penetrating through the interior of the cells,changing the structure of cells,stimulating proliferation and migration,and promoting inflammatory cytokines secretion and calcification.This article reviews the biological activities of VSMCs influenced by P·gingivalis in order to reveal the connection between periodontitis and atherosclerosis and provide some ideas for researches.
Keywords：vascular smooth muscle cellsPorphyromonas gingivalisatherosclerosisbiological activities
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 502-506 )