The clinical role of Maraviroc in the salivary adenoid cystic carcinoma cells
LI Tian-yi
SHEN Zhi-yuan
Abstract：Objective To study the role of the CCR5 antagonists Maraviroc in the migration,chemotaxis,invasion and proliferation of human salivary adenoid cystic carcinoma.Methods Scratches、migration、invasion and MTT assays were performed to detect the migration,chemotaxis,invasion and proliferation of SACC-83 and SACC-LM in vitro.Results Compared with control group,the experimental group which was pretreated by CCR5 inhibitor Maraviroc had lower recuperability in cell scratch model.The number of cells which were blocked by inhibitor decreased significantly on the lower surface of the filters which were fixed in methanol in migration and invasion assays.And proliferation experiment results show that the muhiplication capacity of SACC-83 and SACC-LM were obviously inhibited by Maraviroc.Conclusion Maraviroc may be a kind of new targeted anti-tumor drugs and small-molecule antagonists of CCR5 could inhibit the development of salivary gland adenoid cystic carcinoma.
Keywords：salivary glandsadenoid cystic carcinomaMaravirocCCR5perineural invasion
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 493-496 )