Effect of bioactive hyaluronic acid combined with minocycline hydrochloride on the antibacterial function of Porphyromonas gingivalis
CHEN Fei
ZHUANG De-shu
ZHANG Hong-bo
LUAN Xiao-min
BI Liang-jia
Abstract：Objective To invesigate the combined effect of bioactive hyaluronic acid (B-HA) with minocycline hydrochloride on the antibacterial function of Porphyromonas gingivalis (P.gingivalis),to provide a therory to the clinical of periodontal medicine.Methods Agar dilution method with medicine to measure the survive rate of P.gingivalis,divided into four groups,B-HA separately,minocycline hydrochloride separately,B-HA combined minocycline hydrochloride,control group accordingly.Quantitated the ability of P.gingivalis is growth by counting the number of the visible bacterial colony,and computed the survival rate of P.gingivalis.Results Five different density of B-HA combined the minocycline hydrochloride in a density of 0.05 μg/L,the result showed as the increase of B-HA,the survival rate is decrease gradually (P ＜ 0.05),the survival rate is 82.57％,71.56％ seperately when the density is 35 mg/L and 45 mg/L respectively.The survival rate is 50.46％ when the density is 55 mg/L.Compared to the B-HA alone,it has improved at 22.93％ (P ＜ 0.05).Conclusion Our research show that the combination between B-HA and minocycliue hydrochloride has signifiant effect on the anti-bacterial of P.gingivalis.
Keywords：hyaluronic acidHAPorphyromonas gingivalisminocycline hydrochloridecombined antibacterial effectagar dilution method
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 283-286 )