Influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs.
TAN Nai-wen
ZHANG Si-jia
WEI Hong-bo
XU Xiao-ru
LIU Xiang-wei
REN Shuai
ZHOU Yu-chao
SONG Ying-liang
Abstract：Objective The diabetic pig model was established by intravenous injection of streptozocin in order to investigate whether direct laser metal sintering (DLMS)could improve osseointegration in diabetic animal models.Methods A diabetes model in mini-pigs was established by intravenous injection of streptozotocin (STZ)(150 mg/kg),and a total of 36 implants were inserted into the nandibular region.Micro-computed tomography (micro-CT)and histologic evaluations were performed three and six months after implantation.Results The blood glucose level remained at high level (≥ 10 mmol/L) after the induction of diabetes,reaching the diabetic level (≥ 7 mmol/L).Obvious improvement in osseointegration was observed in the micro-CT and Van Gieson (VG)staining analyses of DLMS implants compared with MAO at three months (P ＜ 0.05),although this difference disappeared by six months (P ＞ 0.05).Conclusion The rough surface of DLMS implants can accelerate the progress of osseointegration.
Keywords：laser manufacturingdental implantsdiabetes mellitusosseointegration
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 270-273 )