Research progress of the relationship between DKK1 gene as well as its gene polymorphisms and oral diseases
LI Dong-mei
XU Chun-jiao
Abstract：DKK1 is an important inhibitor of Wnt signaling pathway,which blocked Wnt signaling mainly through combined with LRP5/LRP6 receptor and Kremen-1/2.DKK1 gene is involved in the process of embryonic development and osteogenic differentiation,and is related to the occurrence and development of many oral diseases.In recent years,the research of DKK1 gene polymorphisms has become a hotspot.It has been found that the DKK1 gene polymorphism sites are related to tooth agenesis.This review summarized the recent research progress of the relationship between DKK 1 gene as well as its gene polymorphisms and oral diseases,and provided the theoretical basis for further studying the role of DKK1 in the development of oral diseases.
Keywords：DKK1gene polymorphismstooth agenesisperiodontitis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 175-179 )