Detection and study of Fusobacteriumnucleatumin the acute exacerbation of chronic obstructive pulmonary disease
TAN Li-si
WANG Hong-yan
ZHAO Hai-jiao
PAN Ya-ping
KANG Jian
Abstract：Objective To detect the presence of Fusobacterium nucleatum(Fn.)in the acute exacerbation of chronic ob-structive pulmonary disease(AE-COPD)and to investigate its relationship with FEV1 and periodontal index. Methods The sputum samples of AE-COPD were collected and were extracted DNA of bacterium. The amount of Fn. and the to-tal number of bacterial cells were determined by real-time PCR based on SYBR@Green I Premix Ex TaqTM. FEV1 and periodontal parameters of each AE-COPD were recorded,and then investigate the relationship between Fn. and FEV1 and periodontal index. The data were statistically analyzed using SPSS17.0 software. Results The detection rate of Fn. was 60.38%and the relative quantity of Fn. was(44.58 ± 16.47)%. There was negative correlation between the relative quantity of Fn. and FEV1(P<0.05). There was positive correlation between the relative quantity of Fn. and simplified oral hygiene index and clinical attachment loss(P<0.05). Conclusion Fn. can colonize in the sputum samples in the AE-COPD and colonization of Fn. is relevant to FEV1 and periodontal parameters.
Keywords：Fusobacterium nucleatumacute exacerbation of chronic obstructive pulmonary diseaseperiodontitis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 664-667 )