Research progress of SIRT1 in suppressing inflammatory response
QU Liu
QIU Li-hong
Abstract：SIRT1,a histone deacetylase which belongs to the sirtuin family,is expressed in most human cells. SIRT1 plays a vital role in glucolipid metabolism and aging. There are emerging results indicating that SIRT1 can inhibit the in-flammatory responses via suppressing several signaling pathways. In this review we outline recent research advances on the biological characteristics of SIRT1,its anti-inflammatory effects and its inhibition to downstream signaling pathway.
Keywords：SIRT1inflammatory responseNF-κBp38 MAPK
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 564-568 )