Expression of histone methyltransferase SMYD3 in endometrial carcinoma and its significance
YE Wei-biao
LI Guang-liu
ZHU Ying
XUAN Wen-ting
LI Zhong-jun
Abstract：Objective To investigate the expression and significance of histone methyltransferase SMYD3 in endometrial carcinoma.Methods Totally 85 patients with endometrial cancer who underwent surgical treatment at The Tenth Affiliated Hospital,Southern Medical University from January 2014 to December 2020 were selected.The expression of SMYD3 in endometrial carcinoma tissue,atypical endometrial hyperplasia tissue,and normal endometrium tissue was assessed by immunohistochemical staining.The correlation between SMYD3 expression and clinicopathological characteristics and prognosis of patients was analyzed.Results The positive rate of SMYD3 expression in the endometrial carcinoma tissue was 83.53％,which was higher than that in atypical endometrial hyperplasia tissue(43.33％)and normal endometrium tissue(26.67％),and the difference was statistically significant(P＜0.05).The expression level of SMYD3 was associated with FIGO stage,lymphovascular space involvement,and lymph node metastasis in patients with endometrial carcinoma(P＜0.05).The patients with higher SMYD3 expression had shorter overall survival time than those with lower SMYD3 expression(P＜0.05).Conclusion The expression of SMYD3 is high in endometrial carcinoma,which is closely correlated with tumour progression and poor prognosis,suggesting that it can be used as a potential prognostic indicator and therapeutic target.
Keywords：histone methyltransferaseSMYD3endometrial carcinoma
Publication Date：2025-10-02
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：4( 1031-1033,1038 )