Differential diagnosis between HELLP syndrome and postpartum hemolytic uremic syndrome
ZHAO Xian-lan
TAO Ya
Abstract：The accurate diagnosis and prompt management of pregnancy-associated complications are crucial for safe-guarding the well-being of both mothers and infants.This is particularly true for diseases presenting with similar clini-cal manifestations yet having markedly distinct treatment strategies.The HELLP syndrome(characterized by hemoly-sis,elevated liver enzymes,and thrombocytopenia)and postpartum hemolytic uremic syndrome(PHUS),as typical examples of pregnancy-related thrombotic microangiopathy(TMA),share comparable clinical features but possess fun-damental pathological disparities.Both diseases have an in-sidious onset and progress rapidly,and misdiagnosis or de-layed diagnosis is not uncommon,which significantly com-promises patient prognosis.Thus,the accurate discrimina-tion between the HELLP syndrome and PHUS is pivotal for enhancing diagnostic and therapeutic efficacy and reducing maternal mortality.This article comprehensively analyzes the similarities and differences in the pathogenesis,clini-cal characteristics,and laboratory findings of the two con-ditions.It proposes a differential diagnosis approach based on multidisciplinary cooperation and underlines the signifi-cance of early recognition in improving prognosis.By re-viewing the latest domestic and international guidelines and clinical practices,key differential diagnostic points are summarized,aiming to offer a reference for clinical de-cision-making.
Keywords：HELLP syndromepostpartum hemolytic uremic syndromedifferential diagnosisthrombotic microangiopathypregnancy complications
Publication Date：2025-09-02
Online Publishing Date：2025-10-20(First online date of this platform, not the publication date of the document)
Pages：4( 883-886 )