Postpartum hemolytic uremic syndrome:pathogenesis and new perspective of multidisciplinary diagnosis and treatment
YANG Hai-lan
HAN Yu
Abstract：Postpartum hemolytic uremic syndrome refers to a serious life-threatening syndrome characterized by acute microvascular hemolytic anemia,thrombocytopenia,and acute renal failure that occurs after childbirth.If not treat-ed,it will lead to a mortalityrate of up to 90％.The etiology is still unknown.Current research suggests that endothelial dysfunction,coagulation fibrinolysis imbalance,and abnor-mal activation of the complement system are the main pathogenesis of this syndrome.Although the incidence is ex-tremely low,the mortality rate is high and the treatment op-tions are limited.In recent years,with the deepening of re-search on the complement system,new treatment methods such as complement inhibitors have brought new hope to PHUS patients.This article elaborates and discusses its pathogenesis,diagnosis and treatment.
Keywords：postpartum hemolytic uremic syndromehemolytic anemiathrombocytopeniarenal failureMDT
Publication Date：2025-09-02
Online Publishing Date：2025-10-20(First online date of this platform, not the publication date of the document)
Pages：5( 879-883 )