Early diagnosis and intervention of pregnancy-associated thrombotic thrombocytopenic purpura
CHEN Jia-min
XI Fang-fang
LUO Qiong
Abstract：Pregnancy-associated thrombotic thrombocyto-penic purpura(TTP)is a rare obstetric complication charac-terized by thrombocytopenia,microangiopathic hemolytic anemia,and multi-organ dysfunction.The hypercoagulable state of pregnancy,combined with deficient or inhibited ADAMTS13 enzyme activity,significantly exacerbates dis-ease risk,resulting in high mortality if untreated.This arti-cle systematically reviews the pathological mechanisms,early diagnostic biomarkers,and intervention strategies for gestational TTP.A multidisciplinary clinical management pathway is proposed and the future research directions based on the latest scientific advances are discussed.
Keywords：thrombotic thrombocytopenic purpuramicroangiopathic hemolytic anemiaADAMTS13plasma exchange
Publication Date：2025-09-02
Online Publishing Date：2025-10-20(First online date of this platform, not the publication date of the document)
Pages：6( 873-878 )