Diagnostic value of hematological indicators in occurrence and development of severe endometriosis

YAN Ying-yan; CHEN Xia-xia; YAN Zeng-ze; SHEN Long-hui; MAO Pei-zhi

doi:10.19538/j.fk2025070118

Abstract：Objective To analyze the differences in hematological indicators among patients with different stages of endometriosis(EM)and non-EM controls,and to explore their diagnostic value in the occurrence and progression of severe EM.Methods This retrospective study included 112 patients with stage Ⅰ or Ⅱ EM(mild group),136 patients with stage Ⅲ or Ⅳ EM(severe group),and 136 patients without EM(control group),all treated at Ningbo Women and Children's Hospital of Ningbo University between December 2022 and May 2024.General and hematological data were collected.Differences among groups were analyzed using pair comparisons,and logistic regression analysis was used to identify factors associated with development of severe EM.The diagnostic performance of relevant markers was assessed using receiver operating characteristic(ROC)curves.Results No significant differences were found between the mild and control groups in general or hematological parameters.Compared with controls and mild cases,the severe group showed significantly elevated levels of fibrinogen(FIB),CA125,CA19-9,and plasma D-dimer(P＜0.05).Logistic regression identified CA125 and FIB as independent predictors of severe EM.The combination of CA125 and FIB yielded an area under the ROC curve(AUC)of 0.834 with sensitivity and specificity of 80.10％and 80.60％,respectively,surpassing single-indicator models.In distinguishing severe from mild EM,the combined model also improved diagnostic sensitivity.Conclution The combination of CA125 and FIB provides a more effective diagnostic approach for identifying and evaluating severe endometriosis,offering a promising noninvasive tool for clinical application.