Predictive value of serum LH level on hCG administration day on live birth rate after in vitro fertilization-embryo transfer treatment
XU Yan-ping
TIAN Ye
SONG Xue-ru
Abstract：Objective To assess the value of the serum luteinizing hormone(LH)level on the human chorionic gonadotropin(hCG)administration day for predicting the live birth rate(LBR)after in vitro fertilization-embryo transfer(IVF-ET)treatment.Methods This was a retrospective cohort study.A total of 378 female patients were included,who underwent IVF-ET treatment with the gonadotropin-releasing hormone(GnRH)antagonist protocol and had their first fresh cycle embryo transfer at Tianjin Medical University General Hospital from June 2017 to April 2024.All patients received ovulation induction treatment with the GnRH antagonist protocol and were divided into a low-LH group(LH ≤1.67U/L)and a high-LH group(LH＞1.67U/L)according to the serum LH level on the hCG administration day.Evaluate the effects of such factors as the LH level on the hCG administration day,body mass index(BMI),and ovarian reserve function on the pregnancy outcome.Results There were no significant differences in the biochemical pregnancy rate,clinical pregnancy rate,or live birth rate between the low-LH group and high-LH group(P＞0.05).However,the regression analysis showed that female age,the number of transferred embryos,and the thickness of the endometrium were significantly correlated with the live birth rate(P＜0.05).The predictive role of the LH level on the hCG administration day in the pregnancy outcome did not show independence,while age and endometrial thickness might be stronger predictors for the live birth rate.Conclusions The LH level on the hCG administration day,as an independent predictor,does not play a significant role in the prediction of the live birth rate after treatment,indicating that it might not be a decisive factor affecting the pregnancy outcome.Nevertheless,such factors as age and endometrial thickness play an important role in predicting the live birth rate,suggesting that the success rate of IVF-ET treatment should be evaluated individually by combining multiple physiological indicators.
Keywords：hCGLHin vitro fertilizationlive birth rateGnRH antagonist
Publication Date：2025-06-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 649-652 )