Study on the effect of injection of compound norethisterone enanthate after induced abortion on the severity of dysmenorrhea and menstrual pattern
WAN Ting
QIN Shuang
YUE Chao-min
XIE Yong-mei
ZHANG Xiao-xia
HUANG Jian-ming
LI Yang-zhi
LI Zhi-min
LEI Xiu-wen
XIONG Xiao-qin
LIU Yu-xian
LI Li-qin
LUO Xiao-wan
DONG Xu-nan
DU Xue-lian
JIN Ping
WANG Xiao-rong
LI Wei-ru
LI li
Abstract：Objective For patients with primary dysmenorrhea who undergo termination of pregnancy in the early stages of pregnancy,inject compound norethisterone enanthate after induced abortion procedure;discuss its effect on menstrual patterns and the severity of dysmenorrhea.Methods From December 2021 to October 2022,a total of 308 early pregnancy patients from 13 public tertiary A hospitals in Guangdong Province who requested termination of pregnancy and had a history of primary dysmenorrhea were treated with injection of compound norethisterone enanthate after induced abortion,and compared the changes in menstrual patterns and dysmenorrhea scores were compared before and after the injection.Result After continuous injection of compound norethisterone enanthate for 3 months following an abortion,the severity of dysmenorrhea gradually decreased.The VAS score for dysmenorrhea before injection was(4.90±1.82),and the scores for the first,second,and third months after injection were(2.97±1.80),(1.58±1.57),and(0.86±1.20)respectively.There was a statistically significant difference before and after treatment(P＜0.001).The average menstruation duration before aboration was(3.26±1.05)days,the average duration of the first menstrual period after injection was(5.57±2.18)days,the average duration of the second menstrual period was(5.56±1.72)days,and the average duration of the third menstrual period was(5.08±1.72)days.Compared with the average duration before injection,there was a statistically significant difference(P＜0.05).Conclusions Immediate injection of compound norethisterone enanthate after abortion has significantly efficacy in the treatment of dysmenorrhea;the impact on menstrual patterns mainly manifests as prolonged spotting during menstruation.With an increase in the cycles of injections,the duration of menstruation gradually shortens,and there is no significant effect on menstrual cycle or total menstrual flow.There are no significant changes in liver and kidney function or coagulation function-related indicators compared to before injection.
Keywords：compound norethisterone enanthateinduced abortionprimary dysmenorrheamenstrual patternscoagulation functionliver and kidney function
Publication Date：2025-05-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 569-572 )