A comparison in the clinical characteristics and prognosis between cold knife conization of the cervix and extrafascial hysterectomy in the treatment of young patients with stage ⅠA1 cervical cancer without LVSI
DU Xin-ying
LIU Ya-na
YAN Shu-ping
FU Han-lin
MAO Meng
WANG Qian
GUO Rui-xia
Abstract：Objective To compare and analyze the clinical characteristics and prognosis of young patients with stageⅠA1 cervical cancer without lymphovascular space invasion by cold knife conization(CKC)and by extrafascial hysterectomy(EH).Methods This study retrospectively analyzed the clinical data of 153 patients(≤45 yeas old)with stage ⅠA1 cervical cancer who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2013 to September 2023.According to different surgical methods,they were divided into CKC group(53 cases)and EH group(100 cases).The clinical characteristics,perioperative indexes and prognosis of the two groups were compared and analyzed,and the fertility outcomes of the patients in the CKC group were followed up.Results Compared with the CKC group,the EH group had significantly longer operation time[(89.0±33.3)min vs.(47.6±26.1)min],first postoperative flatus time[(2.2±0.5)d vs.(1.3±0.5)d],indwelling catheter time[(2.0±0.6)d vs.(1.2±0.4)d]and postoperative hospital stay[(5.3±1.7)d vs.(3.8±1.7)d],and significantly more intraoperative blood loss[(33.2±27.2)mL vs.(13.1±14.6)mL](P＜0.001).In the EH group,6 patients(6.0％)had postoperative complications.The 3-year DFS and OS of both groups were 100.0％(P＞0.05).In the CKC group,the postoperative pregnancy rate was 63.2％(12/19),the live birth rate was 46.2％(6/13),and the premature birth rate was 50.0％(3/6).Conclusions CKC is a surgical procedure with small damage.Patients treated with CKC have a fast postoperative recovery and good prognosis and fertility outcomes,and CKC can be used as a clinical choice for young patients(≤45 years old)with stage ⅠA1 cervical cancer without LVSI.
Keywords：stage ⅠA1 cervical cancercold knife conization of the cervixextrafascial hysterectomyyoung patientsprognosis
Publication Date：2025-03-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 348-352 )