Infection during pregnancy and preterm birth
MI Ya-bing
YING Hao
Abstract：The incidence of Preterm birth(PTB)in China affects 7％of all pregnancies and 70％of spontaneous PTB(sPTB),which is a leading cause of infant morbidity and mortality.30％of pregnancies with intact membranes and 60％of those with pPROM have a clinical or subclinical infection(which is called histological chorioamnionitis).Most of intrauterine infections are caused by ascending pathogens from the lower genital tract and the vagina,which often includes Group B streptococci(GBS),bacterial vaginosis(BV),ureaplasma urealyticum(UU),Chlamydia trachomatis(CT),human papillomavirus(HPV)infections,etc.Extra-uterine infections are also associated with PTB(e.g.,pyelonephritis,pneumonia).For suspected or confirmed clinical infection,antibiotics are the main-stay of treatment and targeted treatment should be also made.If we consider intrauterine infection,delivery should be considered,regardless of the gestational age.Most cases of intrauterine infection during pregnancy are diagnosed by postpartum placental pathology,with a few having obvious clinical symptoms of acute cho-rioamnionitis.It is very difficult for us to treat and in-tervene timely.Therefore,how to prevent and treat intrauterine infections has always been our goal.
Keywords：ascending infectionchorioamnionitispreterm birthantibioticpreventiontreatment
Publication Date：2023-12-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1197-1200 )