Clinical effect of reduced dose gonadotropin releasing hormone agonist long protocol and gonadotropin releasing hormone antagonist protocol in patients with decreased ovarian reserve
XI Si-si
YANG Mu-kun
ZENG Cheng
XU Yang
SHANG Qing
XUE Qing
Abstract：Objective To compare the clinical effect of reduced dose gonadotropin releasing hormone(GnRH)agonist long protocol with that of GnRH antagonist protocol in patients with decreased ovarian reserve in IVF / ICSI cycles. Methods From January 2012 to April 2016,women with decreased ovarian reserve receiving IVF-ET and ICSI in Peking University First Hospital Reproductive Center clinic were included in this study. A total of 84 cycles received controlled ovarian stimulation by using reduced dose GnRH agonist long protocol and another 84 cycles by GnRH antagonist protocol.The pregnant outcomes between the two groups were compared.Results The numbers of oocytes,fertilization embryo,embryo and transferable embryo were significantly higher in reduced dose GnRH agonist long protocol group (5.6 vs. 3.3,3.7 vs. 2.4,3.8 vs. 2.4,3.3 vs. 2.1,P＜0.01). The usage of gonadotropins and duration of controlled ovarian stimulation in GnRH antagonist protocol group were significantly less than that in reduced dose GnRH agonist long protocol group(2591.1U vs. 3402.7U,8.3d vs. 11.3d,P＜0.01). No significant difference was found in implantation rate,clinical pregnancy rate,abortion rate or ectopic pregnancy rate of each fresh embryo transfer cycle between the 2 groups. No significant difference was found in cumulative clinical pregnancy rate of each oocyte retrieval cycle between the 2 groups. Conclusion The advantage of GnRH antagonist protocol is less dosage of gonadotropin. The number of oocyte retrieved and transferable embryo number in reduced dose long protocol are more.
Keywords：decreased ovarian reservereduced dose GnRH agonist long protocolgonadotropin releasing hormone antagonist protocol
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 559-562 )