Analysis of the efficacy and safety of two kinds of conjugated equien estrogens cream in the treatment of atrophic vaginitis
ZUO Hong-ling
LIN Shou-qing
ZHENG Shu-rong
LI Shi-lan
BIAN Mei-lu
LIU Jian-li
HU Lina
GAO Xiao-li
SUN Ai-jun
Abstract：Objective To compare the efficacy and safety of domestic and imported conjugated estrogens cream in the treatment of postmenopausal women with atrophic vaginitis.Methods The trial was conducted between September 2003 and June 2004.The subjects were randomly divided into the test group(domestic conjugated estrogens cream,122 cases) and the control group(imported estrogen cream,118 cases).The treatment course was 21 days.The vaginal mature index (VMI),the atrophic vaginitis evaluation score and vaginal health evaluation score were recorded before and after treatment.The level of follicle stimulation hormone(FSH)and estradiol(E2)in serum and thickness of endometrium were detected before and after treatment.Results Main efficacy indexes:before treatment:the VMI of the test group was 25.15± 23.3 and that of the control group was 29.84±25.29;after treatment:the VMI of the test group was 77.15±21.25 and that of the control group was 78.09±20.56.The VMI was significantly elevated both in test group and control group after treatment(P＜0.01).The difference between the two groups was not statistically significant(P＞0.05).Secondary efficacy indexes:comparison of the total score of atrophic vaginitis showed that before the test group was 4.99± 2.13 and the control group was 4.96 ± 2.22,while after treatment,the test group was 0.79±1.20 and the control group was 0.42±0.83.The total score was significantly reduced both in test group and control group after treatment(P＜0.01);the difference between the two groups was statistically significant(P＜0.05).Comparison of total vaginal health scores showed that before treatment,the test group was 7.34±2.15 and the control group was 7.51±2.16;after treatment,the test group was 15.72±2.53 and the control group was16.02± 2.21.The scores were significantly elevated both in test group and control group after treatment(P＜0.01).The difference between the two groups was not statistically significant(P＞0.05).Safety aspects:serum levels of FSH,E2 and endometrial thickness:the changes after treatment were statistically significant compared with baseline(P＜0.01).There were no significant differences in the rise and decline levels between the two groups(P＞0.05).Conclusion Comparing domestic conjugated equine estrogen cream with imported conjugated equine estrogen cream,the therapeutic effect is similar,both of which can safely and effectively treat the atrophic vaginitis of postmenopausal women and improve their quality of life.
Keywords：conjugated equine estrogen creamatrophic vaginitisscore of atrophic vaginitisvaginal health scores
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 550-554 )