Multicenter clinical study on the effect of two kinds of conjugated estrogen on estrogen level and lipid metabolism in perimenopausal women
ZUO Hong-ling
LIN Shou-qing
GAO Xiao-li
ZHENG Shu-rong
ZHANG Zhen-yu
LIU Hong-wei
WANG Shu-yu
SUN Ai-jun
Abstract：Objective To compare the effects of domestic conjugated estrogen tablets (test group)with imported estrogen tablets (control group)on estrogen level and lipid metabolism in perimenopausal women.Methods The trial was conducted between September 2003 and June 2005.Totally 223 postmenopausal women that from 5 hospitals including Peking Union Medical College Hospital were randomly assigned into two groups:112 cases in the test group and 111 cases in the control group.Drugs were given in a continuous sequential pattern for 4 cycles.The serum estradiol (E2),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),total cholesterol (TC) and triglyceride (TG)were measured before and after the use of drugs.Results The E2 level after treatment increased in both the study group and the control group:in-group comparison:P＜0.05,comparison between groups P＞0.05.Serum lipid level after treatment:HDL-C increased in both the study group and the control group:in-group comparison:P＜0.05,comparison between groups P＞0.05;LDL-C decreased in both the study group and the control group,in-group comparison:P＞0.05,comparison between groups:P＞0.05.TC decreased in both the study group and the control group,and the change in the control group was statistically significant,P＜0.05.comparison between groups:P＞0.05.TG increased in study group and the control group,in-group was comparison:P＜0.05,comparison between groups:P＞0.05.Conclusion The domestic estrogen can improve lipid metabolism and increase the E2 level in menopausal women significantly,and the effect is not inferior to that of the imported estrogen.
Keywords：perimenopause syndromehormone replacement therapyconjugated estrogenestradiollipid metabolism
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 84-88 )