Correlation analysis of perineural invasion and clinicopathological parameters based on big data of cervical cancer in part of mainland China hospitals
LIANG Cong
LI Wei-li
CHEN Chun-lin
LIU Ping
ZHAO Wei-dong
LU An-wei
WANG Shao-guang
NI Yan
ZHU Qian-yong
WANG Wu-liang
KANG Shan
LING Bin
LANG Jing-he
Abstract：Objective To analyze the clinical characteristics and pathological features of patients with perineural invasion by using multi-center data of cervical cancer.Methods The clinical and pathological data of 31 599 patients with cervical cancer were obtained from 34 hospitals in 11 provinces of China from 2004 to 2016.Finally we enrolled 12 931 patients without other treatments before radical hysterectomy in 24 hospitals and retrospectively analyzed the clinical features and their relationship with postoperative pathological factors in patients with PNI.Results The positive rate of PNI in 12 931 cases of cervical cancer was 1.59％ (206/12 931).The positive rate of PNI in patients with stage Ⅱ A cervical cancer was significantly higher than that in patients with stage Ⅰ A-Ⅰ B (x2=122.547,P＜0.01).The positive rate of PNI in endogenous cancer was significantly higher than the other general types of tumor (x2=96.558,P＜0.01).Compared with other pathological types of cervical cancer,PNI was less found in early invasive carcinoma cases (x2=34.071,P＜0.01).The age of PNI-positive group was significantly higher than that of PNI-negative group (t=3.503,P＜0.01).There was no significant difference in terms of histological differentiation,menarche age,number of pregnancies,number of labor,or maximum diameter of tumor between the PNI positive group and the PNI negative group (P＞0.05).The PNI was more likely to be associated with pathological risk factors such as lymph node metastasis,para-uterine metastasis,LVSI,invasive depth and uterine body invasion(P＜0.05).There was no significant difference between the two groups in the risk factors of vaginal resection margin involvement,ovarian metastasis and fallopian tube metastasis (P＞0.05).Multivariate analysis showed that FIGO stage,operative year,cervical invasive depth,LVSI and uterine body invasion were independent risk factors of PNI in cervical cancer(P＜0.05).Conclusion PNI-positive is more likely to occur in endogenous cervical cancer or the cancer with higher FIGO stage,and is less likely to occur in early invasive carcinoma.PNI is more likely to be associated with high risk pathologic factors such as lymph node metastasis,para-uterine metastasis,LVSI,invasive depth and uterine body invasion.FIGO stage,invasive depth greater than 1/2 muscle layer,LVSI,and uterine body invasion are PNI independent risk factors.With the increase of the understanding of PNI,detection rate is gradually increased yearly.
Keywords：cervical cancerperineural invasionbig data
Publication Date：2018-01-01
Pages：6( 72-77 )