Analysis of HPV gene detection of cervical cancer cases in Songyuan region

GUAN Xiu-jun; SUN Da-wei; LIU Jing-wen; LIU Xue-qin; ZHAO Mei

doi:10.19538/j.fk2017120119

Abstract：Objective To investigated the cervical cancer patients information who had infected by human papilloma viruse (HPV)in SongYuan region and the relation between infection information and clinical biological behavior.Methods Using nucleic acid hybridization technique and support reagents to detect HPV typing of 142 women patients who suffered cervical cancer and using statistic analysis to the data.Results There were 138 cases is HPV detecting positive.There were 117 cases with single HPV in fection and 21 cases with multiple HPV types infection in 138 cases.The deference between the two groups has statistical significance (P＜0.01).There were 15 HPV types were identified by this study and 10 HPV types in them with single infection.In order of decreasing positive rate is,HPV16 (66.67％),HPV 18 (5.80％),HPV 31 (2.90％),HPV 45 (1.45％),HPV 33 (2.17％),HPV 58 (1.45％),HPV 59 (1.45％),HPV 6 (1.45％),HPV 56(0.72％)and CP8304(0.72％);Other HPV types were in multiple infections group were HPV11 (2.90％),HPV39 (2.17％),HPV52 (1.45％),HPV66 (0.72％),HPV68 (0.72％).The total positive rate of HPV 16 is 77.54％ which has conspicuous statistical significance than other types (P＜0.01).The total HPV positive rate of HPV 18 has no statistical significance(P＞0.05)with HPV31,HPV 33,HPV 45.The HPV positive rate in different clinical stage groups and different histopathology groups has not statistically significant (P＞0.05).Conclusion A majority of cervical cancer patients were with single HPV infection and approvimately HPV16 was the predominant type followed by HPV18,HPV 31and HPV 45 in Songyuan regions.We have not found that multiple HPV infection can increase the risk of cervical cancer.The HPV infection could not affect the progress of cervical cancer and differentiation of the tumor cells.