Expression of NGF And TGF-β1 in endometrial tissues of adenomyosis and the effect of LNG-IUS on it
GAO Yan-fei
SHI Bin
SHAN Shu-zhi
ZHAO Xin
JIANG Jing
LI Dong-xiao
Abstract：Objective To explore the possible involvement of NGF and TGF-β1 in dysmenorrhea associated with adenomyosis (AM) and molecular mechanism of LNG-IUS in relieving dysmenorrhea.Methods From Feb.2014 to Oct.2015,62 AM patients undergoing hysterectomy or adenomyomectomy in the Second Hospital of Hebei Medical University were enrolled in this study,who were classified into dysmenorrhea group,non-dysmenorrhea group and LNGIUS-treated group based on visual analogue scale (VAS)and LNG-IUS-treatment history.Another 13 cases of fibroid receiving total hysterectomy who were without chronic pelvic pain or dysmenorrhea were included as the control group.The expressions of NGF and TGF-β1 in the eutopic and ectopic endometrium of each group were examined by immunohistochemistry.Results The expressions of NGF and TGF-β1 in the endometrium of dysmenorrhea group were higher than non-dysmenorrhea and control group (P＜0.05),the difference between severe pain patients and mild to moderate pain and painless patients were statistically significant (P＜0.05).The expressions of NGF and TGF-β1 in the endometrium and VAS score had a significant positive correlation.The expressions of NGF and TGF-β1 in the endometrium in LNGIUS-treatment group were lower than dysmenorrhea group (P＜0.05).Conclusion The upregulated expressions of NGF and TGF-β1 in the eutopic and ectopic endometrium are both involved in dysmenorrhea.The suppression of NGF and TGF-β1 by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.
Keywords：adenomyosisNGFTGF-β1dysmenorrheaLNG-IUS
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1283-1287 )