Effect of commonly-used tocolytic drugs on fetuses
LIAN Yan
WANG Xie-tong
Abstract：Most of tocolytic drugs currently in use are not developed specifically to treat preterm labour and have multi-organ side effects.β2-epinephrine agonists,oxytocin receptor blockers and calcium channel blockers are relatively safe for the fetus.The neuroprotective magnesium sulfate on the early preterm children has been affirmed,long-term and large amount of magnesium sulfate for intrauterine exposure may lead to fetal and neonatal bone loss and fracture.Prostaglandin synthetase inhibitors have potentially serious side effects on the fetus and neonate in the third trimester,but are safe in the second trimester.Vaginal progesterone is an effective tocolytic drug with minimal effect on the fetus.
Keywords：spontaneous preterm labourtocolytic drugs
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1144-1148 )