Grading and etiology of ovarian resistant syndrome
HUANG Bao-yi
XU Pei
LIU Man-ting
FU Yang
XU Jia-hui
ZENG Yan-ting
HUANG Ye
LIU Jian-qiao
Abstract：Objective To investigate the grading and etiology of ROS.Methods Totally 6 cases of ROS were collected at the Third Affiliated Hospital of Guangzhou Medical University from September 2015 to December 2016.According to the basic FSH level,the ROS was divided into 3 grades.The first-grade ROS range was 10 U/L≤ FSH＜25 U/L,the second-grade ROS range was 25 U/L≤ FSH＜40 U/L,and the third-grade ROS range was FSH≥40 U/L.Clinical data and blood samples were obtained and genomic sequencing of FSHR and LHCGR was carried out.Results LHCGR mutation (rs2293275,c.935A＞G,p.Asn680Ser)]occurred in all patients and FSHR mutation[(rs6165,c.919A＞G,p.Thr307Ala)and (rs6166,c.2039A＞G,p.Asn680Ser)occurred in some patients.The first-degree ROS patients were able to acquire small amounts of oocytes,while the third-degree ROS patients failed,in the case of large dose of exogenous gonadotropin therapy.Conclusion The rs2293275 mutation may be associated with ROS development and the higher the ROS degree,the lower the response of the follicle to ovulation induction drugs.
Keywords：ovarian resistant syndromegradingetiology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 963-966 )