Evaluation of the screening and anticoagulation therapy for inherited thrombophilias in pregnancy
LIAN Yan
WANG Xie-tong
Abstract：In Han populations,deficiencies in protein S and protein C are most common,and deficiencies in antithrombin are not common,while F Ⅴ L mutation and PGM mutation are rare.Inherited thrombophilias increase the risk of gestational venous thromboembolism,and become a contributory factor rather than a single cause of such placentamediated pregnancy complications.If there are clear indications for treatment,there is no need for any inherited thrombophilias screening.Screening may be useful if the cause is unknown and the positive outcome of inherited antithrombotic screening may affect treatment decisions.The existing evidence suggests that prophylactic use of low-dose aspirin can reduce pre-eclampsia.Regarding the question whether LMWH can reduce the risk of recurrence of placenta-mediated pregnancy complications,the conclusions of single center and multi-center studies are different.Despite limited evidence of efficacy,it is recommended to use selective and personalized anticoagulant therapy to prevent these complications.
Keywords：inherited thrombophiliaspregnancyscreeninganticoagulation therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 678-684 )