Expressions of five markers in endometrial diseases and their clinical significance
LU Ping
WANG Yi
ZHANG Yan
YANG Shuling
LIU Xuan
DONG JiaWei
ZHAO Xin
Abstract：Objective To study the relationship between the expression of p53,PTEN,p16,HER-2 and Ki67 and the occurrence and development of endometrial carcinoma.Methods The expression of p53,PTEN,pl6,HER-2 and Ki67 was determined in 50 cases of normal endometrial tissues,20 atypical endometrial hyperplasia and 75 endometrial carcinoma using immunohistochemistry.Results The positive expression rates of p53,PTEN,p16,HER-2 and Ki67 in normal endometrial tissues and endometrial carcinomas were significantly different (P ＜ 0.05).The expressions of HER-2 and Ki67 in atypical endometrial hyperplasia were significantly higher than those in normal endometrial tissues (P ＜0.05),and the expressions of PTEN and Ki67 in endometrial carcinomas and endometrial atypical hyperplasia were significantly different (P ＜ 0.05).The expressions of p53,PTEN,p16 and HER-2 in type Ⅰ and 11 carcinomas were significantly different (P＜0.05),but the expression of Ki67 were similar (P＞0.05).The expression of p53 was significantly related to histological grade,the depth of myometrial invasion,lymph node metastasis and clinical stage (P ＜0.05).The expressions of PTEN,p16,HER-2 and Ki67 were not related to those clinical pathological features.Conclusion The expression of p53,PTEN,p16,HER-2 and Ki67 is closely related to the occurrence and development of endometrial carcinoma.These markers can be used in the pathological diagnosis of endometrial diseases in the clinical practice work.
Keywords：endometrial carcinomaimmunohistochem-istryp53PTENp16HER-2Ki67
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 636-640 )