Effectiveness and safety of dinoprostone insert for labor induction in women with different cervical maturity
LI Xueyuan
LAO Li
ZHANG Yinghui
GUO Yuewen
JIN Ping
YIN Baomin
WANG Xiaoyi
CHEN Dunjin
LIN Xiaobin
CHEN Xiang
LIN Qinglan
YU Yanping
XU Yanwen
ZHU Bin
QIN Yiwei
CHEN Hui
ZHANG Jianping
AN Shengli
WANG Zhijian
Abstract：Objective To analyze the effectiveness and safety of dinoprostone insert for labor induction in women with different cervical maturity.Methods A total of 798 women in 10 hospitals who used dinoprostone insert for induction at term from January 2010 to December 2014 in the Pearl River Delta of Guangdong province were selected as research subjects (study group).Another 496 pregnant women who were inducted by oxytocin were included as control group.After stratification by Bishop score and primipara,the effectiveness and safety of dinoprostone insert for induction at term were analyzed retrospectively.Results For multipara with a Bishop score of 4～6,the vaginal delivery rate within 24h was higher in the study group (81.82％ vs.66.04％,P=0.013).For primipara with a Bishop score of 4～6,the rate of uterine tachysystole was higher in the study group (4.65％vs.0.99％,P=0.009).Other adverse reactions were similar in the two groups.No significant differences were found in the rate of Apgar score ≤7 at 1-min and 5-min of the neonates between the two groups.Conclusion The effectiveness and safety of dinoprostone insert for induction at term is similar to that of oxytocin.Dinoprostone insert is worthy of being widely applied in clinic.
Keywords：dinoprostone insertoxytocininduction at termsafetyeffectiveness
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 626-631 )