Analysis of the relationship between the risk of preterm delivery in singleton pregnancy and in vitro fertilization and embryo transfer
KANG Huixian
MA Caihong
WEI Yuan
WU Zhangxin
SUN Tao
ZHANG Jin
QIAO Jie
Abstract：Objective To investigate the relationship of the risk of premature delivery among singleton pregnancies with IVF-ET.Methods A group of 563 women who conceived by IVF-ET from January 2012 to January 2013 in obstetric ward of Peking University Third Hospital were chosen as the study group (IVF-ET group),and 1126 women who gave birth during the same period of time in the same hospital were chosen as the case-control group (nature conceived group or NC group) according to their mean maternal age,gravidity and parity.The IVF-ET group was divided into female-factor (n=369),the"pure" male-factor infertility subgroups (n=150) and the unexplained infertility subgroup (n=44).The pregnancy outcomes of these two groups were compared.Results The preterm delivery rate in IVF-ET group was significantly higher than control group (11.90％ vs.6.93％,P＜0.05) IVF-ET singleton pregnancies were associated with an increased risk of pregnancy-induced complications,such as gestationa mellitus diabetes,premature rupture of membranes,previa placenta and postpartum hemorrhages,with statistical significance (P＜0.05).The perinatal mean gestational week was lower than NC group [(38.64±2.16) weeks vs.(39.12±-1.73) weeks,P＜0.05],while low birth weight rate was higher than NC group (8.34％ vs.4.35％,P＜0.05).Within IVF-ET group,the incidence rates of prematurity,PROM,and postpartum hemorrhages in female-factor infertility group were significantly higher than the"pure"male infertility group (P＜0.05).The incidence rates of gestational mellitus diabetes,premature rupture of membranes,previa placenta and postpartum hemorrhages in female-factor infertility group were significantly higher than NC group.The perinatal mean gestational week was lower than "pure" male-factor infertility group and NC group,while low birth weight rate were higher than NC group (P＜0.05).Conclusion The increased rate of prematurity of singleton IVF-ET pregnancies is related to the diseases related to infertility and higher rate of obstetric complication in female-factor infertility women.
Keywords：in vitro fertilization and embryo transfersingletonprematurity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 609-612 )