Application of progestin-primed ovarian stimulation or mild stimulation protocols in patients with diminished ovarian reserve
YU Guo
XIANG Yungai
LI Yan
WAN Lijing
TAN Li
Abstract：Objective To compare the application of progestin-primed ovarian stimulation (PPOS) with mild stimulation protocol in patients with diminished ovarian reserve (DOR) and the different clinical pregnancy outcomes of FET.Methods Retrospectively analyze 431 patients with DOR who underwent IVF-ET in the Second Affiliated Hospital of Zhengzhou University between December 2015 and July 2016,209 of whom received PPOS protocol while 222 patients received mild stimulation protocol.Comparisons of the basic information and laboratory outcome between the two groups were performed by univariable analysis.To calculate the odds ratio for clinical pregnancy adjusted for potential confounders,multivariable Logistic regression was performed.Results PPOS cycles were characterized by significantly lower level of LH in the hCG trigger day [3.63 (2.40,5.46) U/L vs.7.07 (4.04,11.92) U/L,P ＜ 0.05] and lower cycle cancellation rate caused by no dominant follicle growth or premature ovulation (1.44％ vs.7.21％,P ＜ 0.05),while higher ooeytes retrieved and more embryos that could be used,compared with the mild stimulation group (P ＜ 0.05).The clinical pregnancy rate (29.17％) and the implantation rate (14.63％) in the PPOS group were slightly higher than those in the mild stimulation group (19.70％ vs.12.59％,P ＜ 0.05).Multivariate logistic regression analysis showed that the probability of clinical pregnancy was significantly higher in the PPOS group when compared with mild stimulation group (OR=6.79,95％ CI:1.15 ～ 40.06,P=0.035),after adjusted for female age,basal FSH,type of infertility,number of transfer embryos and other variables associated with the probability of clinical pregnancy.Conclusion For DOR patients,compared with mild stimulation protocol,the PPOS protocol can reduce the cycle cancellation rate caused by no dominant follicle growth or premature ovulation,obtain more eggs,more embryos that can be used and optimal embryos to accumulate embryos,then to provide more transplant opportunities.PPOS protocol can offer an option for DOR patients receiving IVF-ET.
Keywords：diminished ovarian reserveprogestin-primed ovarian stimulationmild stimulationclinical pregnancy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 502-506 )