Expression of Hugl-1 and aPKC in serous epithelial ovarian cancer

Abstract：Objective To study the expression and significance of Hugl-1 and apical protein kinasec (aPKC) in serous epithelial ovarian cancer. Methods The expressions of Hugl-1 and aPKC protein in 25 normal epithelial ovarian tissues, 31 benign, 41 borderline and 79 malignant serous ovarian cancer tissues were detected with the method of immunohisto-chemistry. The relationship between the respective expression of Hugl-1 and aPKC in serous epithelial ovarian cancer and various clinicopathologic factors had been analyzed. Results Positive expressions of Hugl-1 in serous ovarian cancers, normal, benign and borderline were 12. 7%, 48%, 58%, 41. 5% respectively. The expressions of Hugl-1 in serous ovarian cancers were significantly lower than those in normal, benign and borderline tissues(P <0. 001). The expressions of aPKC in serous ovarian cancers normal, benign and borderline were 19% ,0,0,0 respectively. The expressions of aPKC in serous ovarian cancers were significantly higher than those in other groups (P < 0.001). The expressions of Hugl-1 and aPKC were respectively related to pathological grade, clinical stage and Lymph node metastasis. There wasn' t correlation between the expressions of the two proteins in serous ovarian cancer(P > 0. 05). Conclusion The two proteins may be involved in the carcinogenesis of serous ovarian cancer.