Expression and clinical significance of HMGA2 in cervical intraepithelial neoplasms and cervical cancer
GAO Shu-jun
XU Qiu-lan
Abstract：Objective To investigate the expression and clinical significance of HMGA2 in cervical intraepithelial neo plasms and cervical cancer and the relationship with HPV. Methods Expression of HMGA2 protein were retrospectively studied by immunohistochemistry in 30 normal cervical tissues, 19 low grade of cervical intraepithelial neoplasms, 16 high grade of cervical intraepithelial neoplasms, 13 cervical squamous cancer. HPV were detected with hybridization in situ. Results The expression of HMGA2 was 26. 67% ,21. 05% ,68. 75% and 76. 92% in normal cervical tissues, CIN Ⅰ, CIN Ⅱ～Ⅲ M and cervical squamous cancer respectively (x~2 =17. 11, P < 0. 001). There was negative correlation between the expression of HMGA2 and HPV infection. Conclusion The abnormality of HMGA2 expression maybe an early event in transformation of cervical cancer. HMGA2 possibility is an intrinsic factor in the transformation for the negative correlation with HPV.
Keywords：high mobility group A2( HMGA2)HPVCINcervical squamous cancer
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 216-218 )