The effect of COX-2 and VEGF on epithelial ovarian cancer prognosis

WANG Min; HE Yi-ni; MA Zhi-hong

Abstract：Objective Analyze and evaluate the normal clinic-pathological characteristics(menopause,FIGO stage,histological grade and types,lymph node transmission,and histological type,chemotherapy)and biochemical factors(COX-2 and VEGF)for prognosis of epithelial ovarian cancer.Methods Analyze the clinic-pathological and biochemical factors which are possible affect ovarian cancer prognosis by univariate analysis and multivariate analysis through COX proportional hazard regression model.Results 183 epithelial ovarian cancer cases were invested,147 of which were followed-up successfully.The three-year survival rate was 48.7 1%.The five-year survival rate was 30.7 1%.Analyzing the 6 clinic-pathological factors and 2 biochemical factors through univariate analysis,the menopause,FIGO stage,histological grade,COX-2 status,VEGF status are associated with prognosis(P＜0.05),while lymph node transmission,histological type and chemotherapy are not associated(P＞0.05).These 5 factors are analyzed by Cox proportional hazard regression model analysis.The result is COX-2 status,FIGO stage,VEGF status,histological grade,are the most important factors for ovarian epithelial ovarian cancer prognosis.The death risk degree for COX-2 positive,FIGO stage,VEGF positive,and histological grade is 2.825,2.292,2.051 and 1.873 respectively.Conclusion By Cox proportional hasard regression model analysis COX-2 status,FIGO stage,VEGF status,histological grade,are the important risk factors prognosis factors for epithelial cancer prognosis.COX-2 positive is the first risk factor for affecting epithelial ovarian cancer.