The study of relationship of hypoxiq-inducible factor-1α expression and clinicopathological features and proliferation in ovarian serous cystadenocarcinoma
TONG Xiao-guang
HOU Ke-zuo
LIU Yun-peng
GAO Yan
ZHANG Dan-ye
Abstract：Objective To evaluate the relationship of hypoxia-inducible factor-1 α (HIF-1α) expression and clinicopatho-logical features and proliferation in ovarian serous cystadenoearcinoma. Methods 52 specimens were examined for the expression patterns of HIF-1α and proliferating cell nuclear antigen(PCNA) with immunohistochemistry. Correlations between HIF-1α expression and clinicopathological features and proliferation were investigate. The data were analyzed with X2test or Fishers exact test. Results HIF-1α high expression rate in high grade or stages Ⅲ and Ⅳ or presence of asci-tes invasive ovarian cancer was 76.0%, 81.3% or 87.1%, respectively, was significantly stronger compared with low grade or stages Ⅰ and Ⅱ or absence of ascites tumors,55.6% ,45.0% or 33.3% , respectively (P < 0.05). HIF-1α high expression rate in younger or older than 50 years old was 62.1% or 69.6% ,respectively,which was no significant difference in HIF-1α high expression based on age(P>0.05). PCNA high expression rate was 67.6% in HIF-1α high expression, whith was significant correlation in invasive cancers (P < 0.01). Conclusion Our findings suggest there is significant correlation between HIF-1α expression and grade, stage, ascites and proliferation in ovarian serous cystadenocarcinoma.
Keywords：hypoxia-inducible factor-1αovarian serous cystadenocarcinomaproliferationpathology
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 620-622 )